Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Naturally occurring mutants inform SHBG structure and function.

Molecular endocrinology (Baltimore, Md.) - 1 Jul 2014

Wu Tsung-Sheng, Hammond Geoffrey L

Abstract excerpt

SHBG transports and regulates the activities of androgens and estrogens. Several single nucleotide polymorphisms in the human SHBG gene have been linked to sex steroid-dependent diseases, including those associated with the metabolic syndrome. The N-terminal laminin G-like domain of SHBG includes binding sites for calcium, sex steroids, and fibulin family members, as well as a dimerization domain. We have found...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium-Binding Proteins
Share to Cricetulus
Share to Dihydrotestosterone

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Estradiol

Share to Extracellular Matrix Proteins

Share to Glycosylation

Share to Protein Multimerization

Share to Sex Hormone-Binding Globulin

Source

Open in PubMed Open full text

Identifiers

PMID: 24892637
DOI: 10.1210/me.2014-1058
PMCID: PMC5414826

Genes

SHBG

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Naturally occurring mutants inform SHBG structure and function.PMID 24892637Read ↗

Human sex hormone–binding globulin variants associated with hyperandrogenism and ovarian dysfunctionSemantic proximity Read ↗

Human sex hormone-binding globulin variants associated with hyperandrogenism and ovarian dysfunction.Semantic proximity Read ↗

Steroid ligands bind human sex hormone-binding globulin in specific orientations and produce distinct changes in protein conformation.Semantic proximity Read ↗

New Insights in the Diagnostic Potential of Sex Hormone-Binding Globulin (SHBG)—Clinical ApproachSemantic proximity Read ↗

Sex Hormone Binding Globulin Deficiency Due to a Homozygous Missense MutationSemantic proximity Read ↗

Evolving utility of sex hormone-binding globulin measurements in clinical medicineSemantic proximity Read ↗

A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.Semantic proximity Read ↗

Catalog of 77 single-nucleotide polymorphisms (SNPs) in the carbohydrate sulfotransferase 1 (CHST1) and carbohydrate sulfotransferase 3 (CHST3) genes.Semantic proximity Read ↗

Genetic variants of sex hormone-binding globulin and their biological consequences.Semantic proximity Read ↗

Impact of sex hormone-binding globulin on the human phenome.Semantic proximity Read ↗

Sex Hormone-Binding Globulin: Gene Organization and Structure/Function AnalysesSemantic proximity Read ↗

SHBG gene promoter polymorphisms in men are associated with serum sex hormone-binding globulin, androgen and androgen metabolite levels, and hip bone mineral density.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.