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Article

Human sex hormone-binding globulin variants associated with hyperandrogenism and ovarian dysfunction.

The Journal of clinical investigation - 1 Apr 2002

Hogeveen Kevin N, Cousin Patrice, Pugeat Michel, Dewailly Didier, Soudan Benoît, Hammond Geoffrey L

Abstract excerpt

The access of testosterone and estradiol to target tissues is regulated by sex hormone-binding globulin (SHBG) in human blood. Serum SHBG levels are low in patients with hyperandrogenism, especially in association with polycystic ovarian syndrome (PCOS) and in individuals at risk for diabetes and heart disease. Here, we identify SHBG coding region variations from a compound heterozygous patient who presented with...

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Source

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Identifiers

PMID: 11927624
DOI: 10.1172/JCI14060
PMCID: PMC150924

Genes

SHBG

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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