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Article

Sex hormone-binding globulin genetic variation: associations with type 2 diabetes mellitus and polycystic ovary syndrome.

Minerva endocrinologica - 1 Dec 2010

Chen C, Smothers J, Lange A, Nestler J E, Strauss Iii J F, Wickham Iii E P

Abstract excerpt

Sex hormone-binding globulin (SHBG) is the primary plasma transport protein for sex steroid hormones and regulates the bioavailability of these hormones to target tissues. The gene encoding SHBG is complex and any of several polymorphisms in SHBG have been associated with alterations in circulating SHBG levels. Epidemiological studies have revealed that low plasma SHBG levels are an early indicator of insulin...

Topics

Diabetes Mellitus, Type 2
Female
Humans
Insulin
Insulin Resistance
Liver
Polycystic Ovary Syndrome
Polymorphism, Single Nucleotide
Protein Isoforms
Sex Factors
Sex Hormone-Binding Globulin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21178921
PMCID: PMC3683392

Genes

SHBG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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