Article

The association between lymphocyte mitochondrial DNA abundance and Stroke: a combination of multivariable-adjusted survival and mendelian randomization analyses

2021-10-28

Abstract excerpt

<h4>Background and Purpose</h4> Mitochondrial dysfunction is associated with increased Reactive Oxygen Species that are thought to drive risk of disease, including stroke. We investigated the association between mtDNA abundance, as a proxy for mitochondrial function, and incident stroke using multivariable-adjusted survival and Mendelian Randomization (MR) analyses. <h4>Methods</h4> Cox-proportional hazard model a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f82d3469-dd89-56e1-9200-f3554d259383
DOI: 10.1101/2021.10.27.21265463

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The association between lymphocyte mitochondrial DNA abundance and Stroke: a combination of multivariable-adjusted survival and mendelian randomization analysesDOI 10.1101/2021.10.27.21265463Read

The association between mitochondrial DNA abundance and stroke: A combination of multivariable-adjusted survival and Mendelian randomization analyses.Semantic proximity Read

Mitochondrial DNA Copy Number as a Marker and Mediator of Stroke PrognosisSemantic proximity Read

Low leukocyte mitochondrial DNA abundance drives atherosclerotic cardiovascular diseases: a cohort and Mendelian randomization study.Semantic proximity Read

Lower mitochondrial DNA abundance in blood cells is associated with higher general morbidity and all-cause mortality: a 30-year prospective epidemiological studySemantic proximity Read

Low mitochondrial copy number drives atherogenic cardiovascular disease: evidence from prospective cohort analyses in the UK Biobank combined with Mendelian RandomizationSemantic proximity Read

Deciphering the genetic and epidemiological landscape of mitochondrial DNA abundance.Semantic proximity Read

Deciphering the genetic and epidemiological landscape of mitochondrial DNA abundanceSemantic proximity Read

The association between mitochondrial DNA copy number, low-density lipoprotein cholesterol, and cardiovascular disease riskSemantic proximity Read

Pandora's Box: mitochondrial defects in ischaemic heart disease and stroke.Semantic proximity Read

Association Between Whole Blood–Derived Mitochondrial DNA Copy Number, Low‐Density Lipoprotein Cholesterol, and Cardiovascular Disease RiskSemantic proximity Read

Mitochondrial DNA haplogroups and risk of transient ischaemic attack and ischaemic stroke: a genetic association study.Semantic proximity Read

Diet-derived antioxidants do not decrease the risk of ischemic stroke: a Mendelian Randomization Study in over 1 million participantsSemantic proximity Read