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Article

Deciphering the genetic and epidemiological landscape of mitochondrial DNA abundance.

Human genetics - 1 Jun 2021

Hägg Sara, Jylhävä Juulia, Wang Yunzhang, Czene Kamila, Grassmann Felix

Abstract excerpt

Mitochondrial (MT) dysfunction is a hallmark of aging and has been associated with most aging-related diseases as well as immunological processes. However, little is known about aging, lifestyle and genetic factors influencing mitochondrial DNA (mtDNA) abundance. In this study, mtDNA abundance was estimated from the weighted intensities of probes mapping to the MT genome in 295,150 participants from the UK...

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Identifiers

PMID: 33385171
DOI: 10.1007/s00439-020-02249-w
PMCID: PMC8099832

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