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Article

The association between mitochondrial DNA abundance and stroke: A combination of multivariable-adjusted survival and Mendelian randomization analyses.

Atherosclerosis - 1 Aug 2022

Martens Leon G, Luo Jiao, Wermer Marieke J H, Willems van Dijk Ko, Hägg Sara, Grassmann Felix, Noordam Raymond, van Heemst Diana

Abstract excerpt

BACKGROUND AND AIMS: Mitochondrial dysfunction is associated with increased reactive oxygen species (ROS) that are thought to drive disease risk, including stroke. We investigated the association between mtDNA abundance, as a proxy measure of mitochondrial function, and incident stroke, using multivariable-adjusted survival and Mendelian Randomization (MR) analyses. METHODS: Cox-proportional hazard model analyses...

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Identifiers

PMID: 35793595
DOI: 10.1016/j.atherosclerosis.2022.06.1012

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