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Article

Low leukocyte mitochondrial DNA abundance drives atherosclerotic cardiovascular diseases: a cohort and Mendelian randomization study.

Cardiovascular research - 2 May 2023

Luo Jiao, Noordam Raymond, Jukema J Wouter, van Dijk Ko Willems, Hägg Sara, Grassmann Felix, le Cessie Saskia, van Heemst Diana

Abstract excerpt

AIM: Mitochondrial DNA dysfunction has been implicated in the pathogenesis of cardiovascular diseases. We aimed to investigate the associations between leukocyte mitochondrial DNA (mtDNA) abundance, as a proxy of mitochondrial function, and coronary artery disease (CAD) and heart failure (HF) in a cohort study and approximate the causal nature of these relationships using Mendelian randomization (MR) in genetic...

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PMID: 36536985
DOI: 10.1093/cvr/cvac182

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