Article

Low mitochondrial copy number drives atherogenic cardiovascular disease: evidence from prospective cohort analyses in the UK Biobank combined with Mendelian Randomization

2021-07-02

Abstract excerpt

<h4>Background</h4> Mitochondrial DNA (mtDNA) content might be involved in the risk of cardiovascular disease. We aimed to investigate the association of mtDNA copy number (mtDNA-CN), as a proxy of mtDNA content, and coronary artery disease (CAD) and heart failure (HF) using multivariable adjusted and Mendelian Randomizations (MR) analyses. <h4>Methods</h4> Multivariable-adjusted analyses were conducted using Cox-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: acc3945b-2cbf-5594-9a65-d23daafbca5a
DOI: 10.1101/2021.07.01.21259854

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Low mitochondrial copy number drives atherogenic cardiovascular disease: evidence from prospective cohort analyses in the UK Biobank combined with Mendelian RandomizationDOI 10.1101/2021.07.01.21259854Read

Low leukocyte mitochondrial DNA abundance drives atherosclerotic cardiovascular diseases: a cohort and Mendelian randomization study.Semantic proximity Read

Association Between Whole Blood–Derived Mitochondrial DNA Copy Number, Low‐Density Lipoprotein Cholesterol, and Cardiovascular Disease RiskSemantic proximity Read

The association between mitochondrial DNA copy number, low-density lipoprotein cholesterol, and cardiovascular disease riskSemantic proximity Read

Mitochondrial DNA copy number and incident heart failure: The Atherosclerosis Risk in Communities (ARIC) studySemantic proximity Read

Association of Mitochondrial DNA Copy Number With Cardiovascular DiseaseSemantic proximity Read

Lower mitochondrial DNA abundance in blood cells is associated with higher general morbidity and all-cause mortality: a 30-year prospective epidemiological studySemantic proximity Read

Mitochondrial DNA Copy Number and Incident Atrial FibrillationSemantic proximity Read

Genetic analysis of mitochondrial DNA copy number and associated traits identifies loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation, and reveals a causal association of mitochondrial function with mortalitySemantic proximity Read

Mitochondrial DNA Content Is Linked to Cardiovascular Disease Patient Phenotypes.Semantic proximity Read

Evaluation of mitochondrial DNA copy number estimation techniquesSemantic proximity Read

Mitochondrial DNA Copy Number (mtDNA-CN) Can Influence Mortality and Cardiovascular Disease via Methylation of Nuclear DNA CpGsSemantic proximity Read

Examining the Association between Mitochondrial Genome Variation and Coronary Artery DiseaseSemantic proximity Read