Article

Murine cytomegaloviruses m139 targets DDX3 to curtail interferon production and promote viral replication

2020-04-17

Abstract excerpt

Cytomegaloviruses (CMV) infect many different cell types and tissues in their respective hosts. Monocytes and macrophages play an important role in CMV dissemination from the site of infection to target organs. Moreover, macrophages are specialized in pathogen sensing and respond to infection by secreting cytokines and interferons. In murine cytomegalovirus (MCMV), a model for human cytomegalovirus, several genes...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f8267dc8-279e-5c86-9a0d-4e44869da698
DOI: 10.1101/2020.04.17.046516

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Murine cytomegaloviruses m139 targets DDX3 to curtail interferon production and promote viral replicationDOI 10.1101/2020.04.17.046516Read

Decoding murine cytomegalovirusSemantic proximity Read

Dual Analysis of the Murine Cytomegalovirus and Host Cell Transcriptomes Reveal New Aspects of the Virus-Host Cell InterfaceSemantic proximity Read

Double-Stranded RNA Binding by a Heterodimeric Complex of Murine Cytomegalovirus m142 and m143 ProteinsSemantic proximity Read

Murine cytomegalovirus evolved a cell-cycle regulator (m54.5) within the highly conserved viral DNA polymerase geneSemantic proximity Read

E2F3-dependent activation of FAM111B restricts mouse cytomegalovirus replication in primate cellsSemantic proximity Read

The Cytomegalovirus M35 Protein Modulates Transcription of <i>Ifnb1</i> and Other IRF3-Driven Genes by Direct Promoter BindingSemantic proximity Read

The BTK-DDX41 axis of the STING pathway is activated during cytomegalovirus lytic infectionSemantic proximity Read

Decoding murine cytomegalovirusSemantic proximity Read

Human cytomegalovirus overcomes SAMHD1 restriction in macrophages via pUL97Semantic proximity Read

Human cytomegalovirus regulates host DNA repair machinery for viral genome integritySemantic proximity Read

The Human Cytomegalovirus pUL145 Isoforms Act as Viral DDB1-Cullin-Associated Factors to Instruct Host Protein Degradation to Impede Innate ImmunitySemantic proximity Read

Necroptosis-based CRISPR knockout screen reveals Neuropilin-1 as a critical host factor for early stages of murine cytomegalovirus infectionSemantic proximity Read