E2F3-dependent activation of FAM111B restricts mouse cytomegalovirus replication in primate cells

Abstract excerpt

Cytomegaloviruses are highly species-specific as they replicate only in cells of their own or a closely related species. For instance, human cytomegalovirus cannot replicate in rodent cells, and mouse cytomegalovirus (MCMV) cannot replicate in human and monkey cells. However, the mechanisms underlying the host species restriction remain poorly understood. We have previously shown that passaging MCMV in human retin...

Topics

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• A549 Cells
• Cytomegalovirus and herpesvirus research
• Herpesvirus Infections and Treatments
• Microarray Analysis
• Mosquito-borne diseases and control
• Mutation
• Poxvirus research and outbreaks
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

2394b728-7eb1-5d07-bbc1-68cfc47b7319

DOI

10.1101/2024.08.02.606359