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The Cytomegalovirus M35 Protein Modulates Transcription of <i>Ifnb1</i> and Other IRF3-Driven Genes by Direct Promoter Binding

2023-03-21

Abstract excerpt

Induction of type I interferon (IFN) gene expression is among the first lines of cellular defence a virus encounters during primary infection. We previously identified the tegument protein M35 of murine cytomegalovirus (MCMV) as an essential antagonist of this antiviral system. M35 localizes to the nucleus and interferes with type I IFN induction downstream of pattern-recognition receptor (PRR) activation. Here, w...

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Identifiers and source

Literature Corpus work
957ab87f-fc13-5b0d-a1a2-4b35cf8b1b65
DOI
10.1101/2023.03.21.533612
Open publication

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The Cytomegalovirus M35 Protein Modulates Transcription of <i>Ifnb1</i> and Other IRF3-Driven Genes by Direct Promoter BindingDOI 10.1101/2023.03.21.533612
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