Article

Characterisation of HLA-restricted T-cell responses to abacavir using lymphocytes from drug-naïve volunteers

2012-01-01

Abstract excerpt

Immune-mediated adverse drug reactions are difficult to predict and can be severe in nature. Recently observed genetic associations highlight the importance of specific human leukocyte antigen alleles in the development of certain reactions. The mechanisms underlying antigen formation and subsequent T-cell activation require further investigation. The drugs abacavir (HLA-B*57:01) and ximelagatran (HLA-DRB*07:01 an...

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Literature Corpus work: f8209270-b272-55c9-a62a-c62abb1283b8
DOI: 10.17638/00010595

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