Article

The prognostic significance of p16INK4a/p14ARF locus deletion and MDM-2 protein expression in adult acute myelogenous leukemia

2000-10-30

Abstract excerpt

BACKGROUND The p16INK4a locus encodes two distinct proteins, p16INK4a and p14ARF. Although p16INK4a and p15INK4b are involved in the phosphorylation of the retinoblastoma (Rb) protein, p14ARF interacts with the MDM-2 oncoprotein antagonizing its function as a suppressor of p53. The role of deletions of p16INK4a/p14ARF and p15INK4b and expressions of MDM-2 in myeloid leukemias and its influence on prognosis remain...

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Literature Corpus work: f80bf207-fa9f-5241-822e-90ff7d7783bb
DOI: 10.1002/1097-0142(20001101)89:9<1976::aid-cncr14>3.0.co;2-n

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