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Article

Deregulation of the TP53/p14ARF tumor suppressor pathway in low-grade diffuse astrocytomas and its influence on clinical course.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Oct 2003

Watanabe Takao, Katayama Yoichi, Yoshino Atsuo, Komine Chiaki, Yokoyama Takakazu

Abstract excerpt

PURPOSE: The chromosome 9p21 region harbors three tumor suppressor genes, p14(ARF), p15(INK4b), and p16(INK4a), all of which can be targets for hypermethylation-associated inactivation in low-grade gliomas. p16(INK4a) and p15(INK4b) are critically involved in the RB1 pathway, whereas p14(ARF) acts as an upstream regulator of the TP53 pathway. The role of each tumor suppressor pathway in low-grade diffuse...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14581362

Genes

CDK4
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Deregulation of the TP53/p14ARF tumor suppressor pathway in low-grade diffuse astrocytomas and its influence on clinical course.PMID 14581362Read ↗

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Alterations in the RB1 Pathway in Low‐grade Diffuse Gliomas Lacking Common Genetic AlterationsSemantic proximity Read ↗

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Promoter hypermethylation and homozygous deletion of the p14ARF and p16INK4a genes in oligodendrogliomas.Semantic proximity Read ↗

Wip1 over-expression correlated with TP53/p14(ARF) pathway disruption in human astrocytomas.Semantic proximity Read ↗

Deregulation of the p14ARF/MDM2/p53 pathway is a prerequisite for human astrocytic gliomas with G1-S transition control gene abnormalities.Semantic proximity Read ↗

Functional evidence for a role of combined CDKN2A (p16-p14(ARF))/CDKN2B (p15) gene inactivation in malignant gliomas.Semantic proximity Read ↗

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