Article

The role and mechanism of transcription factor KLF4 in regulating mitochondrial damage and apoptosis by activating chondrocyte autophagy in osteoarthritis

2025-06-18

Abstract excerpt

<title>Abstract</title> <p>Objective To explore the role and mechanism of transcription factor KLF4 in regulating mitochondrial damage and apoptosis by activating chondrocyte autophagy. Methods Human primary chondrocytes were treated with IL-1β to establish an in vitro osteoarthritis model. KLF4 was overexpressed using lentivirus to intervene in chondrocytes. Cell apoptosis and mitochondrial membrane potential...

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Literature Corpus work: f7f9c08d-afda-52d1-9ffa-496cf4f46924
DOI: 10.21203/rs.3.rs-6854144/v1

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