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TNF-α activates RELA expression via TNFRSF1B to upregulate OPA1 expression and inhibit chondrogenic differentiation of human adipose stem cells

2023-03-14

Abstract excerpt

<h4>Background: </h4> Tumour necrosis factor-alpha (TNF-α), one of the pro-inflammatory cytokines mediating the local inflammatory process in joints, has an inhibitory effect on cartilage formation and has a detrimental effect on stem cell-based cartilage regeneration for the treatment of osteoarthritis (OA). However, the mechanisms behind this inhibitory effect are still poorly understood. Mitochondria are import...

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Literature Corpus work
c3f9b777-30d2-5610-ad20-2025c478ca9e
DOI
10.21203/rs.3.rs-2669166/v1
Open publication

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