Molecular mechanisms of cell death in intervertebral disc degeneration (Review)

Abstract excerpt

Intervertebral discs (IVDs) are complex structures that consist of three parts, namely, nucleus pulposus, annulus fibrosus and cartilage endplates. With aging, IVDs gradually degenerate as a consequence of many factors, such as microenvironment changes and cell death. Human clinical trial and animal model studies have documented that cell death, particularly apoptosis and autophagy, significantly contribute to...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Spine and Intervertebral Disc Pathology