Article

Quercetin activates autophagy suppresses apoptosis, inflammation and cartilage matrix degradation in LPS-induced chondrocytes through targeting AMPK/mTOR/ULK1 signaling pathway

2022-04-13

Abstract excerpt

<h4>Background: </h4> Osteoarthritis (OA) is a chronic joint disease characterised by degeneration of articular cartilage, massive apoptosis of chondrocytes and changes in subchondral bone. Quercetin (QUE), a naturally occurring flavonoid, has shown potent anti-inflammatory effects; however, its effects and underlying mechanisms on OA have seldom been systematically illuminated. In this study, we explored the prot...

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Literature Corpus work: 81b0eddc-2909-519e-b90b-96445357653e
DOI: 10.21203/rs.3.rs-1541634/v1

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