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Exploring the relationship between <i>GBA1</i> host genotype and gut microbiome in the <i>GBA1</i> <sup>L444P/WT</sup> mouse model: Implications for Parkinson disease pathogenesis

2024-12-15

Abstract excerpt

<h4>Background</h4> Heterozygous variants in GBA1 are the commonest genetic risk factor for Parkinson disease (PD) but penetrance is incomplete. GBA1 dysfunction can cause gastrointestinal disturbances and microbiome changes in preclinical models. Mounting evidence suggests that the microbiota-gut-brain axis is potentially implicated in PD pathogenesis. Whether the gut microbiome composition is influenced by ho...

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Literature Corpus work
f7dfd001-a66a-546b-b002-0a706d77f37b
DOI
10.1101/2024.12.15.627490
Open publication

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Exploring the relationship between <i>GBA1</i> host genotype and gut microbiome in the <i>GBA1</i> <sup>L444P/WT</sup> mouse model: Implications for Parkinson disease pathogenesisDOI 10.1101/2024.12.15.627490
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