Article

<i>APOE</i> genotype and sex drive microbiome divergence after microbiome standardization in <i>APOE</i> -humanized mice

2025-04-26

Abstract excerpt

The APOE4 allele is the greatest known genetic factor for sporadic or late onset Alzheimer’s Disease (LOAD). Gut microbiome (GMB) dysbiosis can lead to poorer outcomes in disease. The intersection of sex, APOE genotype, inflammation, and gut microbiota is incompletely understood. Previous studies in humans and humanized APOE mice have demonstrated APOE -genotype specific differences in the GMB. However, most o...

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Identifiers and source

Literature Corpus work: 9c86508e-1655-5a6f-bfe6-7265f6162c8d
DOI: 10.1101/2025.04.25.650741

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