Article

Gba1 deletion causes immune hyperactivation and microbial dysbiosis through autophagic defects

2022-12-15

Abstract excerpt

Mutations in the GBA1 gene cause the lysosomal storage disorder Gaucher disease (GD) and are the greatest genetic risk factor for Parkinson’s disease (PD). Communication between gut and brain and immune dysregulation are increasingly being implicated in neurodegenerative disorders such as PD. Here, we show that flies lacking the Gba1b gene, the main fly orthologue of GBA1 , display widespread innate immune up-r...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fa56b415-ff36-5e47-914c-319c117e40d4
DOI: 10.1101/2022.12.15.520449

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Gba1 deletion causes immune hyperactivation and microbial dysbiosis through autophagic defectsDOI 10.1101/2022.12.15.520449Read

Autophagic dysfunction and gut microbiota dysbiosis cause chronic immune activation in a Drosophila model of Gaucher diseaseSemantic proximity Read

The Uncovered Function of the Drosophila GBA1a-Encoded Protein.Semantic proximity Read

Lysosomal storage, impaired autophagy and innate immunity in Gaucher and Parkinson's diseases: insights for drug discoverySemantic proximity Read

ADrosophilaModel of Neuronopathic Gaucher Disease Demonstrates Lysosomal-Autophagic Defects and Altered mTOR Signalling and Is Functionally Rescued by RapamycinSemantic proximity Read

Functional Analysis of Human GBA1 Missense Mutations in Drosophila: Insights into Gaucher Disease Pathogenesis and Phenotypic Consequences.Semantic proximity Read

Glucocerebrosidase deficiency leads to neuropathology via cellular immune activationSemantic proximity Read

Exploring the relationship between <i>GBA1</i> host genotype and gut microbiome in the <i>GBA1</i> <sup>L444P/WT</sup> mouse model: Implications for Parkinson disease pathogenesisSemantic proximity Read

Drosophila melanogaster Mutated in its GBA1b Ortholog Recapitulates Neuronopathic Gaucher DiseaseSemantic proximity Read

Linking <i>Gba1</i> E326K mutation to microglia activation and mild age-dependent dopaminergic NeurodegenerationSemantic proximity Read

Glucocerebrosidase deficiency leads to neuropathology via cellular immune activation.Semantic proximity Read

GBA1 and The Immune System: A Potential Role in Parkinson's Disease?Semantic proximity Read

The emerging role of autophagic-lysosomal dysfunction in Gaucher disease and Parkinson's diseaseSemantic proximity Read