Microbiome signature of Parkinson's disease in healthy and genetically at-risk individuals.

doi:10.1038/s41591-026-04318-5

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Article

Microbiome signature of Parkinson's disease in healthy and genetically at-risk individuals.

Nature medicine - 1 Jun 2026

Menozzi Elisa, Ren Yani, Geiger Mallia, Macnaughtan Jane, Avenali Micol, Toffoli Marco, Gilles Marine, Calabrese Rosaria, Mitrotti Pierfrancesco, Gallo Luca, Famechon Alexandre, Del Pozo Sara Lucas, Mezabrovschi Roxana, Koletsi Sofia, Loefflad Nadine, Yalkic Selen, Limbachiya Naomi, Clasen Frederick, Yildirim Suleyman, Shoaie Saeed, Blottière Hervé, Morabito Christian, David Aymeric, Quinquis Benoit, Pons Nicolas, Le Chatelier Emmanuelle, Valzania Franco, Cavallieri Francesco, Fioravanti Valentina, Toschi Giulia, Blandini Fabio, Almeida Mathieu, Ehrlich Stanislav Dusko, Meslier Victoria, Schapira Anthony H V

Abstract excerpt

Parkinson's disease (PD) is a major cause of disability. GBA1 variants are the most common genetic risk factor for PD and increase the risk up to 30-fold. Why only approximately 20% of GBA1 variant carriers develop PD remains unknown. Here, by combining clinical and fecal metagenomics data from 271 patients with PD, from 43 carriers of GBA1 variants not manifesting PD symptoms (GBA-NMC) and from 150 healthy...

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Identifiers

PMID: 42010118
DOI: 10.1038/s41591-026-04318-5
PMCID: PMC13279262

Genes

GBA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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