Article

Microbiome signature of Parkinson disease in healthy and genetically at-risk individuals

2025-05-19

Abstract excerpt

<h4>Summary</h4> Parkinson disease (PD) is a major cause of disability with significant personal and system financial implications 1,2 . GBA1 variants are the commonest genetic risk factor for PD and increase the risk up to 30-fold 3,4 . Why only ∼20% of GBA1 variant carriers develop PD remains unknown. Here, by combining clinical and faecal metagenomics data from PD individuals carrying or not GBA1 variants, carr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e1ed977e-c76b-52f4-b7b2-e1997fde88db
DOI: 10.1101/2025.05.19.25327907

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Microbiome signature of Parkinson disease in healthy and genetically at-risk individualsDOI 10.1101/2025.05.19.25327907Read

Microbiome signature of Parkinson's disease in healthy and genetically at-risk individuals.Semantic proximity Read

Elucidating the dysbiotic features of gut microbiome, interaction with the human genome, and utility as a biomarker for treatment of Parkinson’s diseaseSemantic proximity Read

Parkinson’s disease-associated alterations of the gut microbiome can invoke disease-relevant metabolic changesSemantic proximity Read

Integrated multi-cohort analysis of the Parkinson’s disease gut metagenomeSemantic proximity Read

Gut microbiota, 1013 new pieces in the Parkinson's disease puzzleSemantic proximity Read

Metagenomics of Parkinson’s disease implicates the gut microbiome in multiple disease mechanismsSemantic proximity Read

Integrated Multi‐Cohort Analysis of the Parkinson's Disease Gut MetagenomeSemantic proximity Read

Meta-analysis of the gut microbiome of Parkinson’s disease patients suggests alterations linked to intestinal inflammationSemantic proximity Read

Microbiome-based biomarkers to guide personalized microbiome-based therapies for Parkinson’s diseaseSemantic proximity Read

Exploring human-genome gut-microbiome interaction in Parkinson’s diseaseSemantic proximity Read

Gut Vibes in Parkinson's Disease: The Microbiota‐Gut‐Brain AxisSemantic proximity Read

Gut microbiome in Parkinson's disease: New insights from meta-analysisSemantic proximity Read