Article
Interplay of Inflammatory Mediators with Epigenetics and Cartilage Modifications in Osteoarthritis
14 Mar 2018
Abstract excerpt
Osteoarthritis (OA), a degenerative disease of diarthrodial joints, is influenced by mechanical and inflammatory factors with aging, obesity, chronic injuries, and secondary diseases thought to be major factors driving the process of articular cartilage degeneration. Chondrocytes, the cellular component of cartilage, reside in an avascular environment and normally have limited potential to replicate. However,...
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