Article

Neutrophil Plasticity and De Novo DUOX2 Expression in Inflammatory Bowel Disease Pathogenesis: A Review of Single-Cell Transcriptomic Advances and Therapeutic Strategies

2025-11-24

Abstract excerpt

Inflammatory bowel disease (IBD) arises from the interplay of genetic susceptibility, microbial dysbiosis, and dysregulated innate immunity, leading to chronic intestinal inflammation. Recent advances in single-cell and spatial multi-omics technologies have redefined neutrophils as highly heterogeneous and transcriptionally plastic cells rather than short-lived effectors. In the inflamed gut, cytokine gradients, h...

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Literature Corpus work: f7852214-81a1-5ec7-93da-de7b2ff40436
DOI: 10.20944/preprints202511.0146.v2

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