Article

MiDAS - Meaningful Immunogenetic Data at Scale

2021-01-14

Abstract excerpt

Human immunogenetic variation in the form of HLA and KIR types has been shown to be strongly associated with a multitude of immune-related phenotypes. We present MiDAS, an R package enabling statistical association analysis and using immunogenetic data transformation functions for HLA amino acid fine mapping, analysis of HLA evolutionary divergence as well as HLA-KIR interactions. MiDAS closes the gap between infe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f77cb093-35c5-51dd-a5ad-6c1e107f5675
DOI: 10.1101/2021.01.12.425276

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MiDAS - Meaningful Immunogenetic Data at ScaleDOI 10.1101/2021.01.12.425276Read

In silico tools for accurate HLA and KIR inference from clinical sequencing data empower immunogenetics on individual-patient and population scales.Semantic proximity Read

ImmuSeeker: deep mining of immune-related gene family signatures through lineage reconstruction.Semantic proximity Read

<i>In silico</i> tools for accurate HLA and KIR inference from clinical sequencing data empower immunogenetics on individual-patient and population scalesSemantic proximity Read

HATK: HLA analysis toolkit.Semantic proximity Read

Approaching Genetics Through the MHC Lens: Tools and Methods for HLA ResearchSemantic proximity Read

Easy-HLA: a validated web application suite to reveal the full details of HLA typing.Semantic proximity Read

IMGT® at scale: FAIR, Dynamic and Automated Tools for Immune Locus AnalysisSemantic proximity Read

The Human Immunopeptidome Project: A Roadmap to Predict and Treat Immune Diseases.Semantic proximity Read

Structural variation shapes regulatory and evolutionary diversity at the HLA locusSemantic proximity Read

Integration of HLA-DR linkage disequilibrium to MHC class II predictionsSemantic proximity Read

Machine learning reveals limited contribution of trans-only encoded variants to the HLA-DQ immunopeptidomeSemantic proximity Read

SKDM human leukocyte antigen (HLA) tool: A comprehensive HLA and disease associations analysis software.Semantic proximity Read