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Metabolic alterations and immune heterogeneity in gastric cancer metastasis

27 Mar 2025

Abstract excerpt

Cellular metabolic reprogramming supports tumor proliferation, invasion, and metastasis by enhancing resistance to stress and immune clearance. Understanding these metabolic changes within the tumor microenvironment is vital to developing effective therapies. We conducted single-cell RNA sequencing on 11 gastric cancer (GC) samples and eight metastatic lesions, analyzing 92,842 cells across eight cell types,...

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Colorectal Cancer Treatments and Studies
Gastric Cancer Management and Outcomes
Metastasis and carcinoma case studies

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40276776
DOI: 10.1016/j.isci.2025.112296

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