Article

Plasma proteomics identifies an IL-6–associated SAA axis linked to muscle wasting in patients with cancer cachexia

2026-06-15

Abstract excerpt

<h4>Summary</h4> Nearly half of patients with advanced lung cancer develop cachexia, a debilitating syndrome that worsens prognosis. We conducted longitudinal clinical and plasma proteomic profiling of 67 patients with non-small cell lung cancer, with and without cachexia, during first-line treatment. Patients with cachexia at diagnosis exhibited elevated risk of hospitalization and treatment-delaying toxicity. A...

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Literature Corpus work: 63764e55-52dc-509d-b722-559ee382cb07
DOI: 10.64898/2026.06.11.730788

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