Article

Development of Bioisosteric <i>Iboga</i> -alkaloids as Antinociceptive and Anxiolytic Agents with Neuroprotective Effects

2025-02-28

Abstract excerpt

The clinical importance of iboga alkaloids lies in their efficacy in reversing drug addiction and modulating drug tolerance. However, due to safety concerns, their use is restricted to appropriate medical supervision. These alkaloids often cause severe hallucinogenic effects due to differential binding to various brain receptors and cardiotoxicity by blocking the human ether-a-go-go-related gene (hERG) potassium c...

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Literature Corpus work: f75854fd-5523-5358-bf80-9098b63330fd
DOI: 10.1101/2025.02.24.639821

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