Article

Site Selective C-H Functionalization of Mitragyna Alkaloids Reveals a Molecular Switch for Tuning Opioid Receptor Signaling Efficacy

2020-08-14

Abstract excerpt

Mitragynine is the most abundant alkaloid component of the psychoactive plant material “kratom”, which according to numerous anecdotal reports shows efficacy in self-medication for pain syndromes, depression, anxiety, and substance use disorders. We developed a new synthetic method for selective functionalization of the unexplored C11 position of the mitragynine scaffold (C6 position in indole numbering) via the u...

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Literature Corpus work: 7dd6fabe-2281-5127-92a9-cea2dc29e79b
DOI: 10.26434/chemrxiv.12799787.v1

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