Article

Optimizing Tissue Clearing Protocols for Whole-Organoid Imaging of Human Cortical and Retinal iPSC-Derived Models

2025-07-01

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Three-dimensional brain organoids derived from human induced pluripotent stem cells provide valuable in vitro systems for studying human brain development and neurological disorders. However, their dense and heterogeneous structure presents significant challenges for high-resolution imaging, particularly when using conventional histological sectioning, which dis...

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Literature Corpus work: f756fab3-f717-5f8f-8fbe-2d11f8834ae9
DOI: 10.21203/rs.3.rs-6734606/v1

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