Article

Optimizing Tissue Clearing Methods for Improved Imaging of Whole-Mount Retinas

2025-04-19

Abstract excerpt

Gene and cell therapies are promising approaches for restoring vision in hereditary and advanced optic neuropathies. However, these therapeutic approaches must be accurately evaluated through a combination of methods, including advanced imaging, to reach the clinic. We present a whole-mount tissue-clearing methodology to improve imaging of donor neuron integration in the retina following cell transplantation in mi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c1929304-fb59-5872-892d-4b9efc80c7d8
DOI: 10.1101/2025.04.14.648787

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Optimizing Tissue Clearing Methods for Improved Imaging of Whole-Mount RetinasDOI 10.1101/2025.04.14.648787Read

Simplified three-dimensional tissue clearing and incorporation of colorimetric phenotyping.Semantic proximity Read

ADAPT-3D: Accelerated Deep Adaptable Processing of Tissue for 3-Dimensional Fluorescence Tissue Imaging for Research and Clinical SettingsSemantic proximity Read

Cellular and Molecular Probing of Intact Transparent Human OrgansSemantic proximity Read

Optimizing Tissue Clearing Protocols for Whole-Organoid Imaging of Human Cortical and Retinal iPSC-Derived ModelsSemantic proximity Read

Compact refractive dual-channel AOSLO for wide-field imaging in mice reveals microglial interactions with transplanted neuronsSemantic proximity Read

Phenotyping Intact Mouse Bones Using Bone CLARITY.Semantic proximity Read

Spatial proteomic mapping of the human and mouse retina using IBEXSemantic proximity Read

Open-source Photobleacher for Fluorescent Imaging of Large Pigment-Rich TissuesSemantic proximity Read

Whole human organ clearing and multimodal mappingSemantic proximity Read

Single Cell RNA Sequencing Analysis of Mouse Retina Identifies a Subpopulation of Muller Glia Involved in Retinal Recovery From Injury in the FCD-LIRD ModelSemantic proximity Read

Simple and Rapid Tissue Clearing Method for Three-Dimensional Histology of the Pancreas.Semantic proximity Read

Single-cell phenotyping within transparent intact tissue through whole-body clearing.Semantic proximity Read