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Article

Multiscale 3D phenotyping of human cerebral organoids.

Scientific reports - 8 Dec 2020

Albanese Alexandre, Swaney Justin M, Yun Dae Hee, Evans Nicholas B, Antonucci Jenna M, Velasco Silvia, Sohn Chang Ho, Arlotta Paola, Gehrke Lee, Chung Kwanghun

Abstract excerpt

Brain organoids grown from human pluripotent stem cells self-organize into cytoarchitectures resembling the developing human brain. These three-dimensional models offer an unprecedented opportunity to study human brain development and dysfunction. Characterization currently sacrifices spatial information for single-cell or histological analysis leaving whole-tissue analysis mostly unexplored. Here, we present the...

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Identifiers

PMID: 33293587
DOI: 10.1038/s41598-020-78130-7
PMCID: PMC7723053

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