Article

Proximity labeling reveals unique and shared interactomes of unmodified and pyroglutamate amyloid beta in human hippocampus in Alzheimer’s disease

2026-05-17

Abstract excerpt

Amyloid plaques are a hallmark neuropathological feature of Alzheimer’s disease (AD), composed of insoluble amyloid beta (Aβ) peptide. Aβ undergoes post-translational modifications that alter their biophysical properties, aggregation kinetics, and neurotoxicity, creating a heterogeneous pool of species that differentially affect AD pathogenesis. Pyroglutamate-modified Aβ (pEAβ) is a particularly aggregation-prone...

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Literature Corpus work: 973772a2-4249-5fe8-89bb-ed7afbb0d649
DOI: 10.64898/2026.05.13.724866

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