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Article

Inhibitory interneuron progenitor transplantation restores normal learning and memory in ApoE4 knock-in mice without or with Aβ accumulation.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 16 Jul 2014

Tong Leslie M, Djukic Biljana, Arnold Christine, Gillespie Anna K, Yoon Seo Yeon, Wang Max M, Zhang Olivia, Knoferle Johanna, Rubenstein John L R, Alvarez-Buylla Arturo, Huang Yadong

Abstract excerpt

Excitatory and inhibitory balance of neuronal network activity is essential for normal brain function and may be of particular importance to memory. Apolipoprotein (apo) E4 and amyloid-β (Aβ) peptides, two major players in Alzheimer's disease (AD), cause inhibitory interneuron impairments and aberrant neuronal activity in the hippocampal dentate gyrus in AD-related mouse models and humans, leading to learning and...

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Identifiers

PMID: 25031394
DOI: 10.1523/JNEUROSCI.0693-14.2014
PMCID: PMC4099537

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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