Article

Bacterial defenses against a natural antibiotic promote collateral resilience to clinical antibiotics

2020-04-20

Abstract excerpt

<h4>Summary</h4> As antibiotic-resistant infections become increasingly prevalent worldwide, understanding the factors that lead to antimicrobial treatment failure is essential to optimizing the use of existing drugs. Opportunistic human pathogens in particular typically exhibit high levels of intrinsic antibiotic resistance and tolerance 1 , leading to chronic infections that can be nearly impossible to eradica...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f74dc159-72ee-5314-8393-285fde50ff1b
DOI: 10.1101/2020.04.20.049437

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Bacterial defenses against a natural antibiotic promote collateral resilience to clinical antibioticsDOI 10.1101/2020.04.20.049437Read

Universal antibiotic tolerance arising from antibiotic-triggered accumulation of redox metabolitesSemantic proximity Read

In vitro exposure to non-antipseudomonal antibiotics (NAPA) induces <i>Pseudomonas aeruginosa</i> resistance to antipseudomonal antibiotics (APA)Semantic proximity Read

Evolution of Antibiotic Tolerance Shapes Resistance Development in Chronic Pseudomonas aeruginosa Infections.Semantic proximity Read

New alternative therapeutic strategies against Pseudomonas aeruginosa, an opportunistic multi-resistant pathogen with a myriad of virulence factors.Semantic proximity Read

Host-dependent Induction of Transient Antibiotic Resistance: A Prelude to Treatment Failure.Semantic proximity Read

Evolutionary stability of collateral sensitivity to antibiotics in the model pathogen <i>Pseudomonas aeruginosa</i>Semantic proximity Read

Evolution under low antibiotic concentrations: a risk for the selection of <i>Pseudomonas aeruginosa</i> multidrug resistant mutants in natureSemantic proximity Read

R-pyocin-mediated selection reverses pan-drug resistance in <i>Pseudomonas aeruginosa</i>Semantic proximity Read

Antibiotics of the future are prone to resistance in Gram-negative pathogensSemantic proximity Read

The evolution of antimicrobial peptide resistance in <i>Pseudomonas aeruginosa</i> is severely constrained by random peptide mixturesSemantic proximity Read

Alternative Evolutionary Paths to Bacterial Antibiotic Resistance Cause Distinct Collateral Effects.Semantic proximity Read

Evolution under low antibiotic concentrations: a risk for the selection of Pseudomonas aeruginosa multidrug‐resistant mutants in natureSemantic proximity Read