Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolution of Antibiotic Tolerance Shapes Resistance Development in Chronic Pseudomonas aeruginosa Infections.

mBio - 9 Feb 2021

Santi Isabella, Manfredi Pablo, Maffei Enea, Egli Adrian, Jenal Urs

Abstract excerpt

The widespread use of antibiotics promotes the evolution and dissemination of resistance and tolerance mechanisms. To assess the relevance of tolerance and its implications for resistance development, we used in vitro evolution and analyzed the inpatient microevolution of Pseudomonas aeruginosa, an important human pathogen causing acute and chronic infections. We show that the development of tolerance precedes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Chronic Disease
Share to Directed Molecular Evolution

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance, Multiple, Bacterial

Share to Drug Tolerance

Share to Microbial Sensitivity Tests

Share to Pseudomonas aeruginosa

Share to Pseudomonas Infections

Source

Open in PubMed Open full text

Identifiers

PMID: 33563834
DOI: 10.1128/mBio.03482-20
PMCID: PMC7885114

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolution of Antibiotic Tolerance Shapes Resistance Development in Chronic Pseudomonas aeruginosa Infections.PMID 33563834Read ↗

Evolutionary stability of collateral sensitivity to antibiotics in the model pathogen <i>Pseudomonas aeruginosa</i>Semantic proximity Read ↗

Evolutionary stability of collateral sensitivity to antibiotics in the model pathogen Pseudomonas aeruginosa.Semantic proximity Read ↗

Evolution of Habitat-Dependent Antibiotic Resistance in Pseudomonas aeruginosa.Semantic proximity Read ↗

Unlocking the enigma of phenotypic drug tolerance: Mechanisms and emerging therapeutic strategies.Semantic proximity Read ↗

Ecology and evolution of antibiotic persistence.Semantic proximity Read ↗

In vitro exposure to non-antipseudomonal antibiotics (NAPA) induces <i>Pseudomonas aeruginosa</i> resistance to antipseudomonal antibiotics (APA)Semantic proximity Read ↗

Bacterial defenses against a natural antibiotic promote collateral resilience to clinical antibioticsSemantic proximity Read ↗

Alternative Evolutionary Paths to Bacterial Antibiotic Resistance Cause Distinct Collateral Effects.Semantic proximity Read ↗

Antibiotic resistance in Pseudomonas aeruginosa and adaptation to complex dynamic environments.Semantic proximity Read ↗

Evolutionary landscapes of Pseudomonas aeruginosa towards ribosome-targeting antibiotic resistance depend on selection strength.Semantic proximity Read ↗

Mutational background influences P. aeruginosa ciprofloxacin resistance evolution but preserves collateral sensitivity robustness.Semantic proximity Read ↗

Multiple ecological and evolutionary mechanisms drive treatment-induced antibiotic resistanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.