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Article

Host-dependent Induction of Transient Antibiotic Resistance: A Prelude to Treatment Failure.

EBioMedicine - 1 Sept 2015

Kubicek-Sutherland Jessica Z, Heithoff Douglas M, Ersoy Selvi C, Shimp William R, House John K, Marth Jamey D, Smith Jeffrey W, Mahan Michael J

Abstract excerpt

Current antibiotic testing does not include the potential influence of host cell environment on microbial susceptibility and antibiotic resistance, hindering appropriate therapeutic intervention. We devised a strategy to identify the presence of host-pathogen interactions that alter antibiotic efficacy in vivo. Our findings revealed a bacterial mechanism that promotes antibiotic resistance in vivo at...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26501114
DOI: 10.1016/j.ebiom.2015.08.012
PMCID: PMC4588393

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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