Article

Requirements for the Biogenesis of [2Fe-2S] Proteins in the Human and Yeast Cytosol

2024-01-16

Abstract excerpt

<h4>ABSTRACT</h4> The biogenesis of iron-sulfur (Fe/S) proteins entails the synthesis and trafficking of Fe/S clusters, followed by their insertion into target apoproteins. In eukaryotes, the multiple steps of biogenesis are accomplished by complex protein machineries in both mitochondria (ISC) and cytosol (CIA). The underlying biochemical pathways have been elucidated over the past decades, yet the mechanisms of...

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Literature Corpus work: f7401881-319e-5e48-9aad-36faa2ab4515
DOI: 10.1101/2024.01.15.575444

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