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Article

Evolution of the human mitochondrial ABCB7 [2Fe-2S](GS)4 cluster exporter and the molecular mechanism of an E433K disease-causing mutation.

Archives of biochemistry and biophysics - 15 Jan 2021

Pearson Stephen A, Cowan J A

Abstract excerpt

Iron-sulfur cluster proteins play key roles in a multitude of cellular processes. Iron-sulfur cofactors are assembled primarily in mitochondria and are then exported to the cytosol by use of an ABCB7 transporter. It has been shown that the yeast mitochondrial transporter Atm1 can export glutathione-coordinated iron-sulfur clusters, [2Fe-2S](SG)4, providing a source of cluster units for cytosolic iron-sulfur...

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Identifiers

PMID: 33157103
DOI: 10.1016/j.abb.2020.108661
PMCID: PMC7785629

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