Article
Structure-function analysis of NEET proteins uncovers their role as key regulators of iron and ROS homeostasis in health and disease.
Biochimica et biophysica acta - 1 Jun 2015
Tamir Sagi, Paddock Mark L, Darash-Yahana-Baram Merav, Holt Sarah H, Sohn Yang Sung, Agranat Lily, Michaeli Dorit, Stofleth Jason T, Lipper Colin H, Morcos Faruck, Cabantchik Ioav Z, Onuchic Jose' N, Jennings Patricia A, Mittler Ron, Nechushtai Rachel
Abstract excerpt
A novel family of 2Fe-2S proteins, the NEET family, was discovered during the last decade in numerous organisms, including archea, bacteria, algae, plant and human; suggesting an evolutionary-conserved function, potentially mediated by their CDGSH Iron-Sulfur Domain. In human, three NEET members encoded by the CISD1-3 genes were identified. The structures of CISD1 (mitoNEET, mNT), CISD2 (NAF-1), and the plant...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.