Article

Transcriptomic and proteomic Mendelian randomization identifies putative therapeutic targets for thoracic aortic disease

2026-08-26

Abstract excerpt

Thoracic aortic aneurysm and dissection (TAA/D) are life-threatening conditions, for which no disease-modifying pharmacological therapies currently exist. Here, we aimed to identify novel molecular targets for TAA/D, through a drug target Mendelian randomization (MR) analysis. Within a Bayesian approach, we integrated a large genome-wide association study for TAA/D (N=14,409 cases; 64 loci) with transcriptomic and...

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Literature Corpus work: f73fe3c0-d054-5c1a-b35f-4fbb5e2b05f2
DOI: 10.64898/2026.08.24.26361272

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