Multi-Omics Analysis for Pathogenesis and Candidate Therapeutic Target in Thoracic Aortic Aneurysms.

Abstract excerpt

BACKGROUND: Thoracic aortic aneurysm (TAA) is a significant public health concern. We aimed to identify drug targets and understand the pathogenic mechanisms of TAA. METHODS: We employed 4907 circulating proteins as exposure data from a large-scale protein quantitative trait loci study involving 35 559 Icelanders. We used findings from the FinnGen study as the outcome data. We conducted bidirectional Mendelian...

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