Article

Mitochondrial Oxygen Consumption Drives Lung Tumor Hypoxia and Resistance to Therapy via Copy Number Alteration in Mitochondrial Electron Transport Subunit NDUFB5

2026-07-28

Abstract excerpt

<h4>ABSTRACT</h4> Decades of research have shown that tumor hypoxia is associated with resistance to anti-cancer treatments. Analysis of TCGA gene expression profiles indicates that NSCLC is among the most hypoxic of cancers despite the high levels of oxygen in the surrounding lung tissue. Several groups have shown that extrinsic factors such as poorly formed tumor vascular contributes to tumor hypoxia. Here, we...

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Literature Corpus work: f739d4e0-18fa-5714-ab7a-3da94cddab12
DOI: 10.64898/2026.07.27.741033

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