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Article

EGFR Mutations Compromise Hypoxia-Associated Radiation Resistance through Impaired Replication Fork-Associated DNA Damage Repair.

Molecular cancer research : MCR - 1 Nov 2017

Saki Mohammad, Makino Haruhiko, Javvadi Prashanthi, Tomimatsu Nozomi, Ding Liang-Hao, Clark Jennifer E, Gavin Elaine, Takeda Kenichi, Andrews Joel, Saha Debabrata, Story Michael D, Burma Sandeep, Nirodi Chaitanya S

Abstract excerpt

EGFR signaling has been implicated in hypoxia-associated resistance to radiation or chemotherapy. Non-small cell lung carcinomas (NSCLC) with activating L858R or ΔE746-E750 EGFR mutations exhibit elevated EGFR activity and downstream signaling. Here, relative to wild-type (WT) EGFR, mutant (MT) EGFR expression significantly increases radiosensitivity in hypoxic cells. Gene expression profiling in human bronchial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28801308
DOI: 10.1158/1541-7786.MCR-17-0136
PMCID: PMC5668182

Genes

EGFR
RAD50

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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