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Hypoxia-induced activation of NDR2 underlies brain metastases from Non-Small Cell Lung Cancer

2023-03-24

Abstract excerpt

The molecular mechanisms induced by hypoxia are misunderstood in non-small cell lung cancer (NSCLC), and above all the hypoxia and RASSF1A/Hippo signaling relationship. We confirmed that human NSCLC (n=45) as their brain metastases (BM) counterpart are hypoxic since positive with CAIX-antibody (target gene of Hypoxia-inducible factor (HIF)). A severe and prolonged hypoxia (0.2% O2, 48h) activated YAP (but not TAZ)...

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Literature Corpus work
cef29c6b-5b3f-500c-bba1-3cab49a076ef
DOI
10.1101/2023.03.20.533395
Open publication

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Hypoxia-induced activation of NDR2 underlies brain metastases from Non-Small Cell Lung CancerDOI 10.1101/2023.03.20.533395
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