Article

Single-cell transcriptomic profiling of human knee cartilage reveals branching chondrocyte state transitions and extracellular matrix–centered remodeling in osteoarthritis

2026-06-29

Abstract excerpt

<h4>Background</h4> Osteoarthritis cartilage contains heterogeneous chondrocyte states, but molecular programs linked to state transitions within human cartilage remain incompletely resolved using public single-cell data. <h4>Methods</h4> A retrospective reanalysis was conducted of a public human knee cartilage single-cell RNA sequencing dataset (GSE255460) including 8 osteoarthritis donors and 3 non-osteoarthri...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 766dba78-6f95-5867-89b7-b2bd27aeb6c9
DOI: 10.64898/2026.06.24.734199

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell transcriptomic profiling of human knee cartilage reveals branching chondrocyte state transitions and extracellular matrix–centered remodeling in osteoarthritisDOI 10.64898/2026.06.24.734199Read

Single-cell RNA-seq analysis reveals the progression of human osteoarthritis.Semantic proximity Read

Synovial transcriptional clusters link cartilage degeneration to cell-type-specific gene expression in knee osteoarthritisSemantic proximity Read

Single-cell RNA seq analysis identifies the biomarkers and differentiation of chondrocyte in human osteoarthritisSemantic proximity Read

Single-cell RNA sequencing analysis of human chondrocytes reveals cell–cell communication alterations mediated by interactive signaling pathways in osteoarthritisSemantic proximity Read

Integrative epigenomics, transcriptomics and proteomics of patient chondrocytes reveal genes and pathways involved in osteoarthritisSemantic proximity Read

Single‐cell <scp>RNA</scp> sequencing in osteoarthritisSemantic proximity Read

Stratification of knee osteoarthritis: two major patient subgroups identified by genome-wide expression analysis of articular cartilageSemantic proximity Read

Single-cell transcriptome and multi-omics integration reveal ferroptosis-driven immune microenvironment remodeling in knee osteoarthritisSemantic proximity Read

Integrative epigenomics, transcriptomics and proteomics of patient chondrocytes reveal genes and pathways involved in osteoarthritisSemantic proximity Read

Unveiling inflammatory and prehypertrophic cell populations as key contributors to knee cartilage degeneration in osteoarthritis using multi-omics data integrationSemantic proximity Read

Single cell transcriptomics in human osteoarthritis synovium and in silico deconvoluted bulk RNA sequencingSemantic proximity Read

Comparison of the major cell populations among osteoarthritis, Kashin–Beck disease and healthy chondrocytes by single-cell RNA-seq analysisSemantic proximity Read