Mechanistic Insights Into Overloading‐Induced Terminal Differentiation of TMJ Condylar Cartilage at the Single Cell Level

Abstract excerpt

The incidence of temporomandibular joint (TMJ) degeneration has been steadily increasing, with overloading identified as a major risk factor. This condition often leads to condylar cartilage degeneration, significantly affecting patients' quality of life; however, the molecular mechanisms underlying this process remain poorly understood, and effective treatments are still lacking. We utilized single-nucleus RNA...

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