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Enhanced Blood-Brain Barrier Penetrability of BACE1 SiRNA-Loaded Prussian Blue Nanocomplexes for Alzheimer's Disease Synergy Therapy

2024-03-12

Abstract excerpt

Amyloid-β (Aβ) deposition was an important pathomechanisms of Alzheimer’s disease (AD). Aβ generation was highly regulated by beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), which is a prime drug target for AD therapy. Silence of BACE1 function to slow down Aβ production was accepted as an effective strategy for combating AD. Herein, BACE1 interfering RNA, metallothionein (MT) and ruthenium complexe...

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Literature Corpus work
6fd32ecb-80ec-5533-9820-43fa955bd3e5
DOI
10.22541/au.171023610.07919917/v1
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Enhanced Blood-Brain Barrier Penetrability of BACE1 SiRNA-Loaded Prussian Blue Nanocomplexes for Alzheimer's Disease Synergy TherapyDOI 10.22541/au.171023610.07919917/v1
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