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Article

Genetic and epigenetic contributors and mimickers of phenotypic hypoxic-ischemic encephalopathy (HIE).

Seminars in perinatology - 1 Dec 2025

Mietzsch Ulrike, Law Janessa B, Thayyil Basel, Miller Danny E, Wood Thomas R, Natarajan Niranjana, Mohammad Khorshid

Abstract excerpt

Hypoxic-ischemic encephalopathy (HIE) remains one of the leading causes of neonatal morbidity and mortality despite advancement in care. Over 60 % of infants presenting with phenotypic HIE lack a clear identifiable acute sentinel event. Clinical genetic testing in neonates with suspected HIE has uncovered an increasing number of genetic conditions and epigenetic modifications that impair their ability to tolerate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40603154
DOI: 10.1016/j.semperi.2025.152112

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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